(S)-Coriolic acid

Research use only, not for human use.

(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases.

(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury.

(S)-Coriolic acid (25μM) causes mitochondrial structural alterations and injury in bronchial epithelium.(S)-Coriolic acid (30 nM; 6 hours; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation.

(S)-Coriolic acid (0-0.6 mg per mouse; Intranasally once a day for 3 consecutive days) causes severe airway dysfunction, airway neutrophilia, mitochondrial dysfunction and epithelial injury.Animal Model:BALB/c mice (6-8 weeks)Dosage:0-0.6 mg per mouse Administration:Intranasally once a day for 3 consecutive days Result:BALB/c mice developed features of mitochondrial dysfunction such as reduction in mitochondrial membrane potential, reduction in complex IV activity in lung mitochondria, and increase in the levels of cytochrome c in lung cytosol.

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Immunology/Inflammation

Lipoxygenase

Lipoxygenase | Mitochondrial Metabolism | PPAR

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29623-28-7

296.44

C18H32O3

>98% (HPLC)

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C(=C/C=C\CCCCCCCC(O)=O)\[C@H](CCCCC)O

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(-20℃)

With Ice Pack

≥ 2 years